One-step synthesis of Lycopodium alkaloid (-)-huperzine W via Suzuki-Miyaura coupling
نویسندگان
چکیده
منابع مشابه
Synthesis of new styrylarenes via Suzuki-Miyaura coupling catalysed by highly active, well-defined palladium catalysts.
An efficient synthetic route for well-defined palladium(0) complexes [Pd(η(2)-dba)(PPh3)2] (2), [Pd(η(2)-dba)(PCy3)2] (3) and their crystallographic structures is reported. This is the first crystallographic characterization of palladium complexes coordinated with one dibenzylideneacetone and two phosphines. A highly effective, fully controlled method for selective synthesis of mono- (5-9) and ...
متن کاملSelection of boron reagents for Suzuki-Miyaura coupling.
Suzuki-Miyaura (SM) cross-coupling is arguably the most widely-applied transition metal catalysed carbon-carbon bond forming reaction to date. Its success originates from a combination of exceptionally mild and functional group tolerant reaction conditions, with a relatively stable, readily prepared and generally environmentally benign organoboron reagent. A variety of such reagents have been d...
متن کاملSelf-liganded Suzuki-Miyaura coupling for site-selective protein PEGylation.
The discovery and development of palladium-catalyzed carbon–carbon bond formation has revolutionized modern organic chemistry in recent decades. The versatility and robustness of these processes have enabled major progress in total synthesis, materials development, and medicinal chemistry. Currently, a large variety of nucleophiles and electrophiles can be efficiently coupled, and part of the e...
متن کاملSuzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides.
A protocol for the Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides that minimizes protodeboronation is described. A combination of catalytic amounts of Pd(OAc)(2) and SPhos in conjunction with CsF in isopropanol effectively affords a variety of coupled products. Surprisingly, a dramatic temperature dependence in product selectivity was observed.
متن کاملSuzuki-Miyaura cross-coupling optimization enabled by automated feedback.
An automated, droplet-flow microfluidic system explores and optimizes Pd-catalyzed Suzuki-Miyaura cross-coupling reactions. A smart optimal DoE-based algorithm is implemented to increase the turnover number and yield of the catalytic system considering both discrete variables-palladacycle and ligand-and continuous variables-temperature, time, and loading-simultaneously. The use of feedback allo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Natural Products and Bioprospecting
سال: 2012
ISSN: 2192-2195,2192-2209
DOI: 10.1007/s13659-012-0084-2